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In order to study the polypharmacological mechanism of Tougu Xiaotong Capsule (TGXTC),a Traditional Chinese Medicine recipe,network features obtained from TGXTC ligand-target interaction network and drug ligand-target interaction network were analyzed by Cytoscape 2.6.3 software platform.Both TGXTC ligand-target interaction network and drug ligand-target interaction network are similar in the interaction profiles and network features,including degree distribution,betweenness centrality,closeness centrality,characteristic path length and network heterogeneity.In addition,both the networks belong to scale-free network.The molecular mechanism of multi-drugs,multi-targets and multi-pathways is revealed,and TGXTC is shown to be an role of polypharmacology in the treatment of osteoarthritis(OA) by traditional Chinese Medicine (TCM).