Vascular Smooth Muscle Cell Apoptosis is an Early Trigger for Hypothyroid Atherosclerosis

来源 :The 6th China-Russia International Conference on Medicine(第六 | 被引量 : 0次 | 上传用户:aaa110122
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aims: Vascular smooth muscle cell (VSMC) apoptosis is an initial change in endothelial dysfunction followed by and atherosclerosis.Hypothyroidism accelerates atherosclerosis.However, the early events responsible for this pro-atherosclerotic effect are unclear.
其他文献
Aim: Berberine, a natural plant alkaloid isolated from the Chinese herb, Rhizoma coptidis,presented multiple pharmacological effect.However its poor bioavailability limited its applications.Our lab de
Aim: The injury of vascular endothelial cell after metabolic diseases was considered as the major factor to induce vascular complications, which plays an important role in other organ damage.We hypoth
Based on its spatial confinement in cardiomyocytes, neuronal nitric oxide synthase (nNOS) regulates a number of physiologic functions by maintaining nitroso-redox balance.We hypothesize that ischemic
Aim: Cardiac hypertrophy is a primary predicator of progressive heart disease that often results in heart failure.This study was designed to evaluate the effect of miR-328 on cardiac hypertrophy and t
Aim: To investigate the effect of myocardial autophagy after acute myocardial infarction in type 1 diabetic mice.Methods: The study was performed with type-1 diabetic myocardial infarction model.The o
Aits: To investigate the effects and potential mechanisms of phosphocreatine (PCr) in the formation and development of atherosclerosis in ApoE-deficient mice.Methods: Sixty ApoE(-/-) mice were allocat
Aim: To explore the influence of PKMzeta, an autonomously active fragment of atypical PKCs, on naloxone-induced aversive memory in a mice conditioned place aversion (CPA) model.Methods: ZIP, an inhibi
Aim: Magnetic mesoporous silica nanoparticles have attracted great attention due to their extensive applications in drug/gene delivery, MRI imaging, ease of modification and biocompatibility.The goal
Aim: Berberine (BER) presents multiple beneficial biological effects including anti-oxidation, anti-inflammatory and anti-apoptosis properties.However, its poor bioavailability limited its application
Aim: Severe sepsis and septic shock are the serious complications in intensive care unit.The success rate of achievement of the "early 6-h resuscitation goal" with present measures is not agreeable.Me