【摘 要】
：
The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division.Aur-A dysregulation represents an oncogenic event that promo
【机 构】
：
Institute of Cancer Stem Cell, Dalian Medical University China
论文部分内容阅读
The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division.Aur-A dysregulation represents an oncogenic event that promotes tumor formation.Our studies revealed that Aur-A promoted breast cancer metastasis.Aur-A over expression enhanced mammary cell migration by dephosphorylation and activation of cofilin, which facilitates actin reorganization and polymerization.Cofilin knockdown impaired AurA-driven cell migration and protrusion of the cell membrane.Conversely, over-expression of activated cofilin abrogated the effects of Aur-A knockdown on cell migration.
其他文献
Introduction: There is increasing evidence that robotic assistance (RARS) could provide better intraoperative and short-term outcomes than traditional laparoscopic approach (LARS) to rectal cancer sur
Metabolic dysregulation have been considered to play an important role in cancer initiation and progression.The observed shift fi-om oxidative phosphorylation to increased glucose burning renders tumo
Cancer stem cells (CSCs) have received considerable attention.Accumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistance, and metastasis.Development
HECTD3 is an E3 ubiquitin ligase with unknown functions.We show that HECTD3 confers cancer cell resistance to cisplatin.To understand the molecular mechanisms, we performed a yeast-twohybrid analysis
Mitochondria are emerging as intriguing targets for anti-cancer agents.We tested here a novel approach, whereby the mitochondrially targeted delivery of anti-cancer drugs is enhanced by the addition o
As the best-characterized ubiquitin-like protein (UBL), small ubiquitin-related modifier (SUMO) was found to conjugate with a number of proteins to regulate cellular functions including transcription,
Cancer is a class of life-threatening diseases in which abnormal cells divide without control.It is now believed that angiogenesis is obligatory for the growth and progression of solid tumors.Tumor la
We designed and synthesized a new family of aminothiol radioprotectors; the lead molecule, PrC210, was highly radioprotective.Three design elements included: i) small size for efficient transmembrane
Chemotherapy is a common treatment for many cancers, especially for those metastatic cancers.Induced apoptosis is an important mechanism of chemotherapeutic agents to eliminate cancer cells.Apoptosis
Drug resistance is a major cause of failure in cancer chemotherapy.Therefore, identification and combined use of adjuvant compounds that can overcome drug resistance may improve the efficacy of cancer