PH-Responsive Micelles Constructed by PCL-PEG-PCL Triblock copolymer Via Oxime Linkage for Anticance

来源 :2014xi`an Conference of International Society for Maxillofac | 被引量 : 0次 | 上传用户：liu_kun

【摘要】

：

【作者】

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Li Xiao

【机构】

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Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Harbin Medical Univers

【出处】

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2014xi`an Conference of International Society for Maxillofac

【发表日期】

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2014年4期

【关键词】

：

pH-responsive Micelles Oxime linkages Drug delivery system

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　　Purpose: To obtain a pH-responsive Doxorubicin drug delivery system.Methods: A novel and well-defined pH-triggered backbone-cleavable triblock copolymer was successfully synthesized by hydroxyethyl terminal with oxime linked poly(ethylene glycol)(OAPEGOH)ligating with polycaprolactone(PCL).And the triblock copolymer was characterized using fourier transformed infrared spectroscopy(FTIR),nuclear magnetic resonance(NMR),and gel permeation chromatography(GPC)analysis.Doxorubicin(DOX),a model anticancer drug,was encapsulated into PCL-PEG-PCL micelles.

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PH-Responsive Micelles Constructed by PCL-PEG-PCL Triblock copolymer Via Oxime Linkage for Anticance

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