Genome-wide analysis identifies DNA methylation status of CpG islands in fetus related to fetus grow

来源 :2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议 | 被引量 : 0次 | 上传用户:songyong
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
DNA methylation is a crucial genome epigenetic modification that is involved in embryonic development, transcription and chromatin structure.Consistent with these important roles, DNA methylation has been demonstrated to be required for vertebrate early embryogenesis and for regulating temporal and spatial expression of genes for controlling cell fate and differentiation.
其他文献
Phenotypic variations in α-thalassemia mainly depend on the defective α-globin gene number.Genetic modifiers of the phenotype of Hemoglobin H (HbH) disease were poorly reported, apart from β-thalassem
会议
目的:观察翻百草丹参合剂干预治疗2型糖尿病大鼠模型糖、脂代谢和PPAR-γ基因表达水平的分子机制研究.方法:建立2型糖尿病大鼠模型,将90只大鼠随机分为4组,正常对照组15只,T2DM模型组25只,马来酸罗格列酮阳性对照组25只,翻白草丹参合剂(翻白草、丹参、黄芪、五味子、天花粉)中药实验组25只.翻白草丹参合剂采用水萃取方法制备药物制剂,马来酸罗格列酮水溶剂,中药实验组和阳性对照组每日早晚两次灌
会议
Many protein-coding oncofetal genes are highly expressed in murine and human fetal liver and silenced in adult liver.The protein products of these hepatic oncofetal genes have been used as clinical ma
会议
Recurrent genome copy number aberrations are known to be a common feature of many cancers,including Hepatocellular carcinoma (HCC), and their analysis is expected to reveal genes involved in carcinoge
会议
Neural tube defects (NTD) and congenital heart disease (CHD) are the top two birth defects in China and among the world.Genetic factors play an important role in the progression of these diseases as m
会议
Ovarian cancer patients usually have poor prognosis due to late diagnosis and relapse with chemoresistance.It is therefore desirable to exploit new agents and novel targets for ovarian cancer treatmen
会议
We report a potent antitumor effect of berberine, an isoquinoline alkaloid, on GBM.Berberine was found to have an IC50 that is much lower than temozolomide in vitro in U87, U251 and U118 glioblastoma
会议
We report a potent antiturnor effect of berberine, an isoquinoline alkaloid, on GBM.Berberine was found to have an IC50 that is much lower than temozolomide in vitro in U87, U251 and Ul18 glioblastoma
会议
The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome, and the tail of spermatozoa.To investigate the ro
会议
It has been believed that the RNASE1 gene duplications are correlated with the plant-feeding adaptation of foregut-fermenting herbivores.Here, we characterized RNASE1 genes from Caniformia, which has
会议