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Background: Oral propranolol is the first-line therapy for infantile hemangioma (IH).However, its mechanism of action remains unclear.Objective: The aim of this study was to evaluate the change of serum VEGF levels in IH patients who underwent propranolol treatment.Methods: The study included 22 IH patients receiving propranolol treatment.At three time points, including before treatment, one month after treatment and three months after treatment, blood samples were examined by ELISA for serum VEGF expression.