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目的:研究IL-1β经血管外膜给药致VSMC的改变及其与JAK2-STAT3通路的关系。方法:SD大鼠24只,分离左侧颈总动脉,实验组血管外膜包裹含IL-1β(2.5μg)的琼脂缓释悬液,对照组包裹空白琼脂悬液,术后2、8、24、48 h,1、2周分别处
OBJECTIVE: To study the changes of VSMC induced by IL-1β transvascular adventitial and its relationship with JAK2-STAT3 pathway. Methods: Twenty-four Sprague-Dawley rats were divided into two groups: the left common carotid artery was dissected, the experimental adventitial membrane was coated with agar sustained-release suspension containing IL-1β (2.5μg), the control group was given blank agar suspension, 24,48 h, 1,2 weeks respectively