Objectives The alteration of hippocampal plasticity has been proposed to play a critical role in both the pathophysiology and the treatment of depression.In this study,the ability of different classes
Background The efficacy and safety of olanzapine monotherapy are evaluated in Japanese patients from a larger,global study of bipolar depression.
Objectives Mammalian target ofrapamycin (mTOR) is a protein kinase involved in the regulation of translation initiation and protein synthesis required for synaptic plasticity.Recent studies suggest th
目的 研究布南色林片单次给药后的人体药代动力学.方法 经广州市脑科医院伦理委员会审批通过,招募30例健康志愿者并分为3组,每组10人,男女各半,分别单次口服4 mg、8 mg和12 mg布南色林片后,采集0、0.25、0.5、0.75、1、1.5、2、3、4、6、8、12、24、36、48和60 h内动态血标本,采用HPLC-MS/MS测定血浆中布南色林的浓度,最后用DAS 3.2.4软件对试验数
目的 探讨精神分裂症患者智力和记忆、持续注意、执行功能之间的关系,以便更加准确的理解精神分裂症患者智力的真实情况.方法 选取符合国际疾病分类标准第十版(ICD-10)之相应诊断标准的住院精神分裂症患者120例(男56例,女64例,平均年龄(35.91±12.02)岁;平均发病年龄(26.46±7.59)岁;平均病程(9.29±9.47)年;平均受教育年限(13.04±3.01)年)及60例健康正常
Objective Mirtazapine,an antagonist for central α2-adrenergic autoreceptors and heteroreceptors,and postsynaptic 5-hydroxytryptamine2 (5-HT2) and 5-HT3 receptors,achieves its unique therapeutic effect
Objectives Recent studies have demonstrated that antidepressant effect of N-Methyl-D-aspartate (NMDA) antagonist ketamine activates rapidly the mammalian target of rapamycin (mTOR) pathway and increas
Objective Accumulating evidence from human genetic and animal model studies implicates the pituitary adenylate cyclase-activating polypeptide (PACAP) signaling pathway as a risk factor for psychiatric
Objective Cognitive deficits are a fundamental feature of the psychopathology of schizophrenia.Abundant evidence supports atypical antipsychotic medications such as olanzapine can improve the neurocog
Objective Population pharmacokinetics can predict antipsychotic plasma concentration at a given time point prior to an actual dosage change.This in turn can be used to estimate a corresponding dopamin