【摘 要】
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There is limited information about the role of cervical epithelial cells in genital innate immunity against herpes simplex virus type 2(HSV-2)infection.We thus examined whether human cervical epitheli
【机 构】
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ABSL-3 Laboratory at the Center for Animal Experiment,State Key Laboratory of Virology,Wuhan Univers
【出 处】
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第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
论文部分内容阅读
There is limited information about the role of cervical epithelial cells in genital innate immunity against herpes simplex virus type 2(HSV-2)infection.We thus examined whether human cervical epithelial cells can be immunologically activated to produce antiviral factors that inhibit HSV-2 replication.Human cervical epithelial cells expressed functional toll-like receptor 3(TLR3)and retinoic acid-inducible Ⅰ(RIG-Ⅰ),which could be activated by double-strand RNAs(dsRNA),resulting in the induction of endogenous interferon lambda(IFN-λ.).
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