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OBJECTIVE Propane-2-sulfonic acid octadec-9-enyl-amide (N15), an analogue of oleoylethanolamide (OEA), is a novel PPARα/γ dual agonist.Our previous studies verified the positive effects of OEA on the acute and delayed stages of cerebral ischaemia.However, it is not clear whether N15 is effective against ischaemic cerebral injury.In the present study, male Kunming mice were subjected to middle cerebral artery occlusion (MCAO).