【摘 要】
：
目的:研究小分子活性肽儿茶酚抑素(catestatin,CST)在两肾—夹肾性高血压大鼠发病中的表达及其意义.方法:SD大鼠30只,随机均分为假手术6周组(normal)和两肾—夹手术6周组(2K1C).颈总动脉压力容积导管测量平均颈动脉压(mCAP)与左心功能;以(左心室+室间隔)/体重的重量比[(LV+ S)/BW]作为左心肥大指数;Western blotting测定组织CST前体嗜铬粒蛋白
【机 构】
：
温州医科大学低氧医学研究所,浙江温州325035
【出 处】
：
中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会
论文部分内容阅读
目的:研究小分子活性肽儿茶酚抑素(catestatin,CST)在两肾—夹肾性高血压大鼠发病中的表达及其意义.方法:SD大鼠30只,随机均分为假手术6周组(normal)和两肾—夹手术6周组(2K1C).颈总动脉压力容积导管测量平均颈动脉压(mCAP)与左心功能;以(左心室+室间隔)/体重的重量比[(LV+ S)/BW]作为左心肥大指数;Western blotting测定组织CST前体嗜铬粒蛋白A(chromogram A,CHGA)表达;RT-qPCR测定组织CHGA mRNA表达.高效液相色谱-电化学方法检测血浆中儿茶酚胺类物质和组胺的含量.
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