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目的 Advanced nasopharyngeal carcinoma(NPC)is an aggressive disease with no targetedtherapies and poor outcomes.New innovative targets are urgently needed.方法 we examined the expression of klf4 in human NPC(n=152)with a tissueimmunohistochemistry(IHC)assay,and performed klf4 knockdown stable cell line withtwo different small hairpin RNAs(shRNAs)to evaluate the impact of klf4 on NPC.