A Palladium catalyzed Negishi-type α-arylation of α-fluoroketones with electron-rich and electron-deficient aryl halogen and phenyl triflate has been developed.This direct mono-α-arylation method operationally simple and enables the labeling of a variety of halogenated (hetero)arenes and phenyl triflate to generate a variety of ternary α-aryl-α-monofluoroketones easily in good to excellent yields using XPhos as ligand and Cs2CO3 as mild base.In view of the ease of conducting such reactions and the relative mild reaction conditions,we expect this protocol to be widely adapted in synthetic chemistry.