Antibodies Targeting the IgE Pathway for Treating Severe Asthma and Allergy

来源 :2013首届世界健康大会 | 被引量 : 0次 | 上传用户:itshuai
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Two types of antibodies are being developed to target soluble IgE in the blood and membrane-bound IgE (mIgE) on IgE-expressing B lymphoblast and memory B cells, for treating allergy and asthma.An ordinary anti-IgE antibody, if were injected into a person, would most likely cause massive activation of mast cells and basophils and probably anaphylactic shocks.Both types of the antibodies being developed to target the IgE pathway can avoid this deadly effect of an ordinary anti-IgE antibody.
其他文献
Psoriasis is a chronic inflammatory skin disease that affects nearly 2% of the worlds population and has substantial detriment on the quality of life.Psoriasis is a complex interaction between numerou
会议
The number of people affected with chronic inflammatory diseases of airways such as asthma and chronic obstructive pulmonary disease (COPD) are growing globally.Corticosteroids and/or β2 adrenergic ag
会议
Aim: We examined the correlations between the pretreatment values of four tumor markers (squamous cell carcinoma [SCC]-antigen, carcinoembryonic antigen [CEA], carbohydrate antigen [CA] 19-9,and CA 12
T helper 17 cells are a recently identified subset of T cells that play normal physiological role in defense against fungi and intracellular organisms.On the other hand, aberrant over-activation of Th
会议
Human umbilical cord mesenchymal stem cells (HUMSCs) are good candidates for tissue engineering.Here we explored their biological features and differentiation capability.The cell surface marker, cell
会议
Many related researches are in processing to investigate MSC cell fate for genetic, epigenetic, cell cycle regulation, immune regulatory and microenvironment.Especially, disruption of epigenetic regul
会议
HIV and SIV pathogenic infection is characterized by early CD4+ T cell dysfunction.Using a protocol of optimized in vitro anti-CD3/28 mediated expansion of enriched CD4+ T cells, we have been able to
会议
Reputed experts, international organizations and leading biomedical journals warn that the greatest risk to human health comes in the form of antibiotic-resistant bacteria.World Health Organizaton dec
会议
The herpes simplex virus (HSV-2) can be acquired through sexual activity and has the ability to establish latent infection in host cells.Infection occurs when virions come in contact with abraded skin
会议
Autoimmune mechanisms are involved in the development of diabetes.Intra bone marrow-bone marrow transplantation (IBM-BMT) + thymus transplantation (TT) has been shown to reduce the incidence of graft
会议