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Locoweed is a poisonous plant,which wildly distributed in most area of the world,it can cause livestock poisoning or death with significant economic loss.The Astragalus strictus belongs to a species of locoweed.It is mainly distributed in Tibet of China and is a serious hazard to the local livestock industry.The objective of this study is extracting and purifying condition of Swainsonine from Astragalus strictus with the microwave-assisted extraction method.An optimum extracting technology of SW from Astragalus strictus was investigated through the orthogonal experiment under the microwave assistance conditions,then the content of swainsonine was analyzed with gas chromatography(GC)method.The optimized extraction conditions were as follow: at room temperature,the time of using the petroleum ether ultrasonic to make the Swainsonine degreased with ultrasonic was 1h,and then use the method of extraction with microwave-assisted,solid-liquid ratio (M∶ V) 1∶10,microwave frequencies 280W,extraction time 20 s.Under the above conditions,the extraction percentage of the swainsonine was 0.009264%.Extracting swainsonine with microwave-assisted extraction method has characteristics of rapid,efficient,convenient and low energy consumption.It is benefit for producing swainsonine from Astragalus strictus.