【摘 要】
：
The study of regional serotonin synthesis in humans by imaging could enable researchers to obtain a better understanding of affective disorders and to develop better therapies.Objective:To perform ima
【机 构】
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Department of Neurology and Neurosurgery McGill University Canada
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
The study of regional serotonin synthesis in humans by imaging could enable researchers to obtain a better understanding of affective disorders and to develop better therapies.Objective:To perform imaging of regional brain serotonin (5-HT) synthesis with labelled α-methyl-L-tryptophan in the normal and affected brain,as well as in the animal models of depression.Methods:Studies were performed on laboratory animals using two different rat models of depression,where the synthesis was measured by autoradiography,and a 14C labelled tracer.Positron emission tomography (PET) with an 11C-labelled tracer was used in the human studies,on both normal subjects and on patients with various brain disorders (e.g.,epilepsy,depression,obsessive compulsive disorder,borderline personality disorder,and those suffering from migraines).Results:The experiments in rats have shown that 5-HT synthesis is elevated in bulbectomized rats (a model of agitated depression) and reduced in the Flinders Sensitive Line rats (a model of retarded depression),and that antidepressants (e.g.,citalopram,buspirone) have the effect of returning the synthesis to the level of the control rats without having a significant effect on plasma Trp concentration.
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