论文部分内容阅读
Aim:Study on the effect of miRNAs targeted delivery system to prostate cancer.Methods:This study designed polyamidoamine (PAMAM) nanoparticle as drug carriers,miR-15a/miR-16-1 as model drug,aptamer (A10-3.2) as prostate-targeting ligand,prostate-specific membrane antigen (PSMA) as target,and all these co-constructed miRNAs targeted nanoparticle mediated by apta mer (PAMAM-PEG-A10/miRNA).