Three new dimers of phenolic amides, named lyciumamides A(3), B (4) and C (5), along with two known monomers, N-E-coumaroyl tyramine (1) and N-E-feruloyl tyramine (2), were isolated from the fruits of Lyciumbarbarum for the first time, with help of the activity-guided chromatographies.Phenolic amides were also firstly found in the genus Lycium.Their structures were determined using spectral analysis and comparing with literature values.Compounds 1-5 were evaluated for their antioxidant activities in scavenging DPPH free radical and inhibiting lipid peroxidation in rat liver microsomes induced by ascorbate/Fe2+, cumine hydroperoxide or CCl4/reduced form of nicotinamide-adenine dinucleotide phosphate,and the results showed that all of them exhibited strong activities while compounds 1 and 2 were more potent than the reference BHA.The data supported that these phenolic amides played an important role on the natural antioxidant properties of the fruits of L.barbarum, similar to other phenolic constituents such as flavonoids and phenolic acids of the fruits.1 In conclusion, the results complemented the current knowledge of the antioxidative composition of the fruits of L.barbarum and confirmed that this agricultural product contained phenolic amide compounds, which might offer interesting potential applications in the food, cosmetic, and pharmaceutical industries.