论文部分内容阅读
Purpose: Optimized preparation of insulin-lauryl sulfate complex loaded poly (lactide-co-glycolide) nanoparticles; Methods: The complex nanoparticles were prepared by a modified emulsion solvent diffusion method.Central composite design and response surface methodology were employed to optimize the drug recovery of insulin-loaded PLGA nanoparticles; Results: the maximum drug recovery of nanoparticle reached 91%; Conclusion: With SDS complex strategy, hydrophilic insulin can be effectively formulated into PLGA NS with relative high drug recovery and content.Central composite design (CCD) can be used to optimize drug recovery, which is dependent to PLGA/insulin and PVA/acetone.