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  5. Optimal Sequential Enrichment Designs for Phase Ⅱ Clinical Trials

Optimal Sequential Enrichment Designs for Phase Ⅱ Clinical Trials

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：itwmh
【摘 要】
：
In the early phase development of molecularly targeted agents(MTAs),a commonly encountered situation is that the MTA is expected to be more effective for a certain biomarker subgroup,say marker-positi
【作 者】
：
Yong Zang Ying Yuan 
【机 构】
：
Department of Biostatistics,Indiana University,46202,USA
【出 处】
：
上海交通大学
【发表日期】
：
2016年4期
【关键词】
：
subgroups personalized medicine molecularly targeted agents phase Ⅱ trials 
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　　In the early phase development of molecularly targeted agents(MTAs),a commonly encountered situation is that the MTA is expected to be more effective for a certain biomarker subgroup,say marker-positive patients,but there is no adequate evidence to show that the MTA does not work for the other subgroup,i.e.,marker-negative patients.
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