As the growth pole of regional economic development, the pathway that airport economy leads the development of regional economy includes: changing the regional elements endowment in the micro scale, couphng with the regional industries in the medium scale, accelerating the tax revenue increase and employment growth in the macro scale.As a representative of Chinese airport economy, Zhengzhou Airport Economic Zone (short for ZAEZ) has played a significant leading and demonstrating role in the following fields: deepening the system reforms in an all-round way, promoting the "synchronization of five modernizations ", building " one cartier and four systems ", constructing " Four Henan ", advancing the structural reform of supply-side and integrating the resources of Henan airport.The article concludes: the structural reform of supply-side needs to be accelerated to integrate into the international frontiers of airport economy.Airport economy is promising under the "One Belt, One Road" initiative.The ZAEA development has promoted the innovation of regional development pattern and showed the tendency of new " four modernizations" of the future regional development.The airport economy has developed rapidly based on the international aviation transportation system, which may change the traditional development pattern that the regional development center located in the coastal areas usually since the Industrial Revolution, and open up a new era that the regional development center will return to the inland regions.