芳香烃受体AhR通过抑制NLRP3转录负向调节NLRP3炎性小体活化

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：camel1650

【摘要】

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【作者】

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怀婉婉宋慧赵婧张磊韩丽辉赵伟

【机构】

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山东大学医学院免疫学系

【出处】

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中国免疫学会第九届全国免疫学学术大会

【发表日期】

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2014年8期

【关键词】

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炎性小体 NLRP3 AhR

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研究背景:NLRP3炎性小体是由模式识别受体NLRP3、ASC和Caspase-1组成的分子平台,其表达水平和活化状态与多种疾病的发生发展密切相关.NLRP3是炎性小体形成的关键分子,其表达水平与炎性小体的活化密切相关.然而,NLRP3在转录水平的调控尚不清楚.芳香烃受体AhR是一种配体依赖活化的转录因子,其配体包括环境污染物二恶英的主要成分TCDD、内源性的体内代谢产物如色氨酸代谢物FICZ等.AhR通过结合在靶基因的特异性序列(XRE)上,调控相关基因的表达调控,影响多种生理、病理进程.通过对小鼠NLRP3启动子区的分析,我们发现在NLRP3的启动子区存在潜在的AhR结合位点,提示AhR可能参与NLRP3的表达调控.

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芳香烃受体AhR通过抑制NLRP3转录负向调节NLRP3炎性小体活化

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