Objective:To explore the possible impact factors of intra-operative hypertension during irreversible electroporation. Methods:47 patients with tumors in varies locations received irreversible electroporation during July to December of 2015. Their tumor location, clinical characteristics, underlying disease, anesthesia method, and hemodynamic data during IRE ablation were recorded and compared. Results:general anesthesia plus continuous epidural anesthesia is related to more stable intra-operative hypertension. In cases whose tumor and adjacent vessel had no lung tissue in between, their distance was another factor in influencing intra-operative blood pressure. Phentolamin was able to control elevated blood pressure effectively. Conclusions:One of the possible mechanism of irreversible electroporation lead to hypertension is by stimulating muscle layers of adjacent major blood vessels. Thus continuous epidural anesthesia, which compromised reaction of blood vessel, could offset this reaction. Loner distance from tumor region to adjacent vessel also decreases this effect.