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Aim: to investigate the association between vitamin D receptor polymorphisms and circulating 1,25-Dihydroxyvitamin D (1,25(OH)2D) levels with keloid scar (KS) risk.Methods: A total of 261 patients with KS and 261 normal healthy individuals were enrolled.VDR gene polymorphisms were determined.Circulating 1,25(OH)2D levels were detected.