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Pterocephali herba is the whole herb of the perennial plant Pterocephalus hookeri (C.B.Clarke) H(o)eck, a member of the Dipsacaceae family.As a traditional national medicine, P.hookeri has been widely applied in many Tibetan herbal medicine formulations and is clinically used to treat diseases including common cold, rheumatoid arthritis, enteritis, dysentery, and other conditions.However, the chemical constituents of P.hookeri had not been clarified yet.Therefore, the chemical profiling of P.hookeri was explored using ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry technology (UPLC-Q-TOF-MS).As a result, 40 compounds were identified, including iridoid glycosides, phenolic acids, triterpenes, alkaloids, lignans.In conclusion, this established UPLC-Q-TOF MS method was reliable and effective for identification of the constituents of P.hookeri.The findings could be benefit for quality control of P.hookeri during production, and provide helpful chemical information for exploring its efficacy and the mechanism of action.