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Objective To investigate the effects of arsenic trioxide(As2O3) on the expression of ezrin and serum alpha-fetoprotein(AFP) level in hepatocellular carcinoma (HCC).Methods 24 patients with resectable HCC,ranged from 42-74 years old(mean age 58.6),were treated with venous injection of As2O3 for 14days(10 mg/d).The ezrin expression level and the serum AFP levels were assessed and compared before and after the treatment,their correlation was analyzed afterwards.Restlts The serum AFP level showed the statistical significant difference(P<0.05).The high serum AFP levels and high experssion of ezrin correlated significantly(P<0.01).