Syphilis is the third leading epidemic diseases around the world and in China,affecting at least 25 million persons worldwide.T.pallidum ssp.pallidum is the known pathogen for syphilis;however,not all the strains conduct severe infections in clinic.The question of what lead to such significant pathogenetic difference remains unexplored yet.With no doubt,decoding genome of T.pallidum provides a shortcut to unveil the difference.