【摘 要】
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Gestational hypercholesterolemia increases susceptibility to mitochondrial dysfunction.This study was aimed to determine whether the gestational hypercholesterolemia could induce mitochondrial dysfunc
【机 构】
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School of Public Health,Beijing Key Laboratory of Environmental Toxicology,Capital Medical Universit
【出 处】
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首都医科大学公共卫生学院第六届研究生学术论坛
论文部分内容阅读
Gestational hypercholesterolemia increases susceptibility to mitochondrial dysfunction.This study was aimed to determine whether the gestational hypercholesterolemia could induce mitochondrial dysfunction in term human placenta A nested case-control study in which eligible pregnant women were recruited from Xuanwu Hospital in Beijing during their first prenatal visit(before their 10th week of pregnancy)was established in this study.Pregnant women whose serum total cholesterol(TC)levels higher than 7.25mM at third trimester(measured at 36~38 weeks)were selected as gestational hypercholesterolemia.Nineteen pregnant women with gestational hypercholesterolemia(HC)and other nineteen pregnant women with normal cholesterol level(NC)matched with age,pre-gestational body mass index(BMI),and the gender of neonate as control were included.Comparison of the parameters measured between NC and HC group mothers(n = 19 for each group)and their placentas were carried out.Full term placenta samples were collected to measure mitochondrial DNA copy number and mRNA expression of COX1,ATP6ase,PGC1-β,and ERR-a and mitochondrial respiratory chain enzyme complex activities.Pregnancy outcomes were obtained by extraction from medical records and the labour ward register.Compared to the NC group,placental mtDNAcopy number and mRNA expression level of ATP6ase of HC group were significantly decreased.Activities of placental mitochondrial respiratory enzyme complex in HC group were lower than that of NC group except complex Ⅲ,and the differences were all not significant.These findings indicated that gestational hypercholesterolemia induced decreased placental biogenesis and function.
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