【摘 要】
：
Background Dysfunction of gap junctional intercellular communication (GJIC) is a common characteristic of tumorigenesis.Each connexin presents tissue or cell-specific expression, and gap junction gene
【机 构】
：
Department of Hematology,Xinqiao Hospital,The Third Military Medical University
论文部分内容阅读
Background Dysfunction of gap junctional intercellular communication (GJIC) is a common characteristic of tumorigenesis.Each connexin presents tissue or cell-specific expression, and gap junction gene Connexin 43 (Cx43) is the major component in hematopoietic tissue.Our previous studies showed that expression of Cx43 and functional GJIC decreased in acute leukemic bone marrow stromal cells (BMSCs), which might be involved in the occurrence of leukemia.All-trans retinoic acid (ATRA) has been demonstrated to increase GJIC function in various of cancer cells.However, the effect of ATRA on the GJIC function in leukemic BMSCs still remains unknown.In this study, we evaluated the effects of ATRA on both Cx43 expression and GJIC, including their succedent biological influence on leukemic BMSCs.
其他文献
目的 总结难治性缺铁性贫血为首发的阵发性睡眠性血红蛋白尿症(PNH)的临床特点.方法 对难治性缺铁性贫血进行PNH筛查,评价其血象、尿常规、乳酸脱氢酶水平及PNH克隆规模,并给予PNH相应治疗.结果 52例PNH中8例以难治性缺铁性贫血首发,单纯贫血3例,2系以上减少5例.补铁治疗有效至铁剂治疗无效的时间1～6个月(中位1.5个月),8例患者中7例LDH高于正常上限1.5倍,6例PNH克隆超过10
目的 总结输血依赖型非重型再障(non severe aplastic anemia,NSAA)患者的临床特点及转归,提高对NSAA患者的重视.方法 收集2014年02月至2015年05月于我院就诊的43例NSAA患者临床资料,予检测骨髓常规及活检,统计临床病程、输血频率、并发症及转归.结果 随访中位时间: (1)输血依赖型NSAA中男性患者28例,女性15例;中位年龄29岁(3-80岁),＜18
目的 探讨上调Rap1GAP对白血病细胞株HL-60体外侵袭能力的影响,并构建白血病动物模型验证体外实验的结果.方法 实时定量PCR及Westen blot检测已构建的Venus/HL-60细胞(CON)及Rap1GAP过表达单克隆细胞株Rap1GAP/HL-60 (R1、R2)的Rap1 GAP表达水平,Transwell方法检测CON、R1、R2细胞株体外侵袭能力,实时定量PCR检测不同细胞株
目的 本研究旨在了解患者行异基因造血干细胞移植术后发生侵袭性真菌感染的发病率、危险因素及转归情况，为allo-HSCT术后的患者IFI的预防和治疗提供依据。方法 将我院2005年01月至2014年09月进行allo-HSCT的79例血液病患者的情况进行回顾性分析，对年龄、性别、原发疾病、造血干细胞来源、HLA相合情况、供受者血型相合情况、预处理方案、ATG的使用情况、移植季度、aGVHD的发生与分
目的 针对血液病房革兰氏阴性菌医院感染的临床特点和病原学变迁进行研究,提高血液科医院感染临床诊治水平.方法 于实验医学科临床微生物室获取华西医院血液科病房五年革兰氏阴性菌医院感染患者病原学信息,制定资料采集表格,查阅住院病历,对患者的临床特点及院感病原学变迁进行统计学分析和研究.结果 2010年至2014年五年间共检出革兰氏阴性菌753株,来自673例次医院感染患者.该组患者中428例次(63.6
Aim Chemotherapy can increase treatment-related mortality associated with future hematopoietic stem cell transplantation (HSCT) for patients with relapsed/refractory acute myeloid leukemia (AML).There
Objective Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme in tryptophan catabolism that plays an important role in the induction of immune tolerance.Although its detailed mechanism of act
Objective Some studies have found that donor-recipient KIR ligand compatibility or incompatibility influences the prognosis of hematopoietic stem cell transplantation between unrelated individuals, al
Aim The bone marrow microenvironment provides leukaemia cells with a relative sanctuary from cytotoxic drugs and forms minimal residual diseases (MRD) and chemoresistance.The present niche models conc
Background Peripheral-blood (PB) and bone marrow (BM) are both widely used in hematopoietic stem cell transplantation (HSCT).However, it has been controversial whether the use of PB or BM leads to a m