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  5. Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance in vitro

Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance in vitro

来源 :2016第九届世界癌症大会 | 被引量 : 0次 | 上传用户：jy860500
【摘 要】
：
Recent studies have suggested that mechanisms linked to the decreased intracellular drug accumulation such as reduced extracellular pH,increased intracellular pH,or linked to the altered intracellular
【作 者】
：
Eliska Ruzickova Petr Dolezel Petr Mlejnek 
【机 构】
：
Department of Anatomy Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic
【出 处】
：
2016第九届世界癌症大会
【发表日期】
：
2016年7期
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　　Recent studies have suggested that mechanisms linked to the decreased intracellular drug accumulation such as reduced extracellular pH,increased intracellular pH,or linked to the altered intracellular drug distribution due to the increased drug sequestration in lysosomes,may play an important role in the drug resistance.
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