Obstructive sleep apnea (OSA) is a common sleep and breathing disorder resulting in intermittent hypoxia (IH), and can cause neurocognitive deficits including impairment in attention, planning and memory.It is well known that learning and memory involves long-term potentiation (LTP), a form of synaptic plasticity.In a mouse model of OSA, we found that chronic (> 7 days) IH treatment (90 s cycles between 10% and 21% O2levels for 8 hrs) impaired both early-and late-phase LTP in the hippocampal slices, which was accompanied by impairment in spatial reference memory as assessed by the radial arm maze test.