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Objective Monocyte adhesion and transendothelial migration play a key role in atherosclerosis.Here we study the effect of Chemerin on adhesion and transendothelial migration of human monocytes.Methods HUVECs were cultured in vitro.Human CD14+ monocytes were isolated by flow cytometry technique.To study the effect of chemerin on adhesion of monocytes in the method of monocytes and HUVECs co-culture ,and to study the effect of chemerin transendothelial migration of monocytes in the method of transwell migration.Results The recombinant human Chemerin can significantly promote monocytes adhesion and transendothelial migration in a dose-dependent manner which could be inhibited by chemerin neutralizing antibody (P <0.05)(the number of adherent monocytes :control group 4.00±3.37/vision, Chemerin 100ng/ml 26.75±4.57/vision, 200ng/ml 32.25±16.38/vision, 300ng/ml 48.25±19.50/vision, P were 0.006,0.001,0.000 respectively ,compared with the control group ;the 4amount of migrated monoyctes :the blank control (0.763±0.042)× 10 cells,100ng/ml (1.17±0.153)×104 cells, 200 ug/L (1.60±0.100)× 104 cells, 500 ug/L (1.87±0.058)× 104 cells, P values all were less than 0.001 compared with the blank control).Conclusion Monocyte adhesion and transendothelial migration play a key role in atherosclerosis.Recombinant human Chemedn can significantly promote human monocytes adhesion and transendothelial migration.It suggests that Chemerin may be involved the occurrence and development of atherosclerosis by influencing the function of monocytes.