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Ligustrazine(tetramethyl pyrazine,TMP,a major effective component of Chinese traditional herbal medicine Chuanxiong,has been reported to be a multifunctional drug in the treatment of cardiovascular diseases(CVDs),with pharmacological activities such as anti-platelet aggregation,free radical scavenge effect and protection against endothelial cells injury1,2.Nowadays ligustrazine is widely used in China for CVDs therapies.