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  5. Down-regulation of NTCP in proliferating Hepatocyte is mediated by cyclin D1 and p53

Down-regulation of NTCP in proliferating Hepatocyte is mediated by cyclin D1 and p53

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户：Tianic
【摘 要】
：
Background: Na+/taurocholate co-transporter polypeptide(NTCP),localized on the membrane of human hepatocytes,is the main hepatocellular sodium-dependent co-transporter protein for uptaking bile acid.N
【作 者】
：
Jingting Kang Jie Wang Jin Cheng Zhiliang Cao Ran Chen Huiyu Li Jianhua Sui Xiangmei Chen Fengmin Lu 
【机 构】
：
Department of Microbiology & Infectious Disease Center,School of Basic MedicalSciences,Peking Univer
【出 处】
：
第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
【发表日期】
：
2015年6期
【关键词】
：
NTCP HBV cccDNA Hepatocellular carcinoma cyclin D1 p53 cell proliferation surviv 
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　　Background: Na+/taurocholate co-transporter polypeptide(NTCP),localized on the membrane of human hepatocytes,is the main hepatocellular sodium-dependent co-transporter protein for uptaking bile acid.NTCP also acts as a functional hepatocyte receptor responsible for the entry of hepatitis B virus(HBV)infection.Previous studies indicated that the expression of NTCP may be affected by the proliferating status of hepatocyte.However,the underlying mechanism remains elusive.
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