Transforming growth factor-beta (TGF-β) suppresses T cell function to promote tumor immune escape.The essential roles of B7-H3 and B7-H4 have been uncovere
Background: TRIM31, an E3 ubiquitin ligase, is a member of the tripartite motif-containing protein (TRIM) family composed of a RING-finger, a B-box and a co
immunotherapy is the hot spot in the treatment of tumor.After undergoing active immunotherapy, passive immunotherapy and adoptive cellular immunotherapy, pe
Anisomycin, an antibiotic produced by Streptomyces, strongly induces apoptosis in different histological sorts of cancer cells in vitro, superior dramatical
Background: The pro-inflammatory cytokine interleukin-6 (IL-6) represents a keystone cytokine in infection, cancer and inflammation.Recent studies suggest t
Objective: Protein kinase C (PRKC) is a family of serine/threonine kinases, and these PRKC isozymes have crucial roles in diverse cellular signaling process