目的 An attempt to analyze reasons for Pulmonary cryptococcosis misdiagnosis clinically,radiologically,and pathologically has been delivered in this paper.方法 We present here a case study of three HIV-negative patients with pulmonary cryptococcosis,each of whom exhibited classical clinical picture of bacterial pneumonia or pulmonary tuberculosis and was initially misdiagnosed and managed with antibiotics or anti-TB therapy until pathological examination confirmed the definitive diagnosis of pulmonary cryptococcosis.