【摘 要】
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Aim:To synthesis a novel chitosan derivative,N-octyl-N-arginine chitosan(OACS),with a mimetic structure of Arginine rich Peptides.OACS micelles loaded Insulin (
【出 处】
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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
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Aim:To synthesis a novel chitosan derivative,N-octyl-N-arginine chitosan(OACS),with a mimetic structure of Arginine rich Peptides.OACS micelles loaded Insulin (Ins-OACS) was prepared,characterized and evaluated.Methods:Octyl groups were introduced onto chitosan by nucleophilic addition and the subsequent reduction.And the formed products were conjugated with arginine under the catalysis of EDC and NHS to form OACS.The structure of OACS was evaluated by elemental analysis,spectrophotometry,FT-IR,1H NMR etc.
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