【摘 要】
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Alantolactone,a sesquiterpene lactone component of roots of Anula helenium has been reported to exhibit anticancer activity in various human cancer cells of
【机 构】
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CollegeofBasicMedicalSciences,DalianMedicalUniversity
【出 处】
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第六届中国细胞生物学学会HIPPO年会暨大连医科大学2016年生命科学学术交流会
论文部分内容阅读
Alantolactone,a sesquiterpene lactone component of roots of Anula helenium has been reported to exhibit anticancer activity in various human cancer cells of multiple origins.In the present study,we found that alantolactone effectively inhibits growth,induces apoptosis and augments doxorubicin anticancer activity in A549 lung cancer cells.The anti-proliferative activity of alantolactone was found to be associated with down-regulation of Ki-67,Myc and cyclin D 1.Induction of apoptosis was found to be associated with mitochondrial dysfunction and endoplasmic reticulum (ER) stress as evident by mitochondrial membrane potential dissipation,Bcl-2 family proteins modulation and induction of ER stress-related proteins,respectively.
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