【摘 要】
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IL-1 is a potent catabolic cytokine that causes suppression of chondrocyte collagen type Ⅱ and proteoglycan synthesis and stimulates chondrocyte-mediated release of cartilage destructive enzymes, incl
【机 构】
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Immunology Abbvie Inc.USA
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IL-1 is a potent catabolic cytokine that causes suppression of chondrocyte collagen type Ⅱ and proteoglycan synthesis and stimulates chondrocyte-mediated release of cartilage destructive enzymes, including major metalloproteinases (MMPs) and ADAMTSs.IL-1α and IL-1β are two isoforms of IL-1 that both interact with IL-1R type Ⅰ.
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