Alendronate prevents dexamethasone-induced osteonecrosis of the femoral head in the rat

来源 :中华医学会第十八届骨科学术会议暨第十一届COA国际学术大会 | 被引量 : 0次 | 上传用户:ebugdoor
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  Background:Osteonecrosis of the femoral head(ONFH) frequently results in collapse of the necrotic portion and subsequent degenerative joint disease of the hip,which is the most common diagnosis leading to total hip arthroplasty in young adults. Biphosphonates(BPs) therapy has been reported to retard osteoporosis,however,the effect of BPs on the prevention of glucocorticoid-induced ONFH is still controversy due to the lack of laboratory investigations.
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