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  5. BDNF stimulates the survival and growth of human spinal cord neurons by Wnt/β-catenin signaling path

BDNF stimulates the survival and growth of human spinal cord neurons by Wnt/β-catenin signaling path

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：weidaxia888
【摘 要】
：
BDNF has critical function in promoting survival and growth of neurons, but its downstream regulation mechanism is still not fully understood.In order to explore whether BDNF can play a role by Wnt/3-
【作 者】
：
Jin Ru Liyan Li Jianhui Guo Jinwei Yang Yongsheng He Jia Liu 
【机 构】
：
Kunming Medical University, Yunnan Kunming 650500,China
【出 处】
：
The 18th Congress of the International Federation of Associa
【发表日期】
：
2014年8期
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BDNF has critical function in promoting survival and growth of neurons, but its downstream regulation mechanism is still not fully understood.In order to explore whether BDNF can play a role by Wnt/3-catenin pathway in human embryonic spinal cord neurons, we successfully cultured hESC-NC and found the number and cell viability were increased after transfected by plRES2-ZsGreen l-BDNF plasmid.Expression of Wnt, Frizzled, Dsh were up-regulated in by Real-time PCR and Western blot, particularly GSK-3β down-regulated.
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