The crosstalk between oxidative stress and PARP-1 methylation involved in the anatase titanium dioxi

来源 :全国卫生毒理学术研讨会 | 被引量 : 0次 | 上传用户:lyh327
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  Objective To study the regulating mechanisms of the anatase titanium dioxide nanoparticles(TNPs)-induced cell toxicity.Methods A549 cells were treated with the anatase titanium dioxide nanoparticles for 24h.A549 cells were also pretreated with methylation inhibitor agent,5-aza and the ROS scavenger α-LA to assess the possible role of methylation and ROS in TNPs-induced cell toxicity.
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