Type 2 diabetes has become a global pandemic and imposes a growing burden to people and society.Although multiple treatment options are available,there remain unmet medical needs for better and safer
Epigenetic modifications such as histone methylation induced by "obesogenic environment" are important contributors to the sharp increase of obesity and diabetes prevalence over past 30-40 years.
Chronic exercise has beneficial effects on protecting against obesity-related metabolic dysfunction.However,the underlying molecular mechanisms are incompletely understood.
In eukaryotic cells,accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes ER stress,activating the adaptive cellular unfolded protein response (UPR).
Proteins and lipids are two major classes of transport cargos serving specific physiological functions.How these distinct biomolecules are differentially sorted through the secretory pathway,however,r
Adipose tissues (ATs) deposit in multiple locations throughout the body such as subcutaneous,visceral and perivascular regions,showing various morphology and physiological functions.
There are two fundamental ways of combating obesity: to decrease energy intake or to increase energy expenditure.Brown adipose tissue (BAT) and beige fat are the major tissues in rodents,which functio
The Non-Alcoholic fatty liver disease (NAFLD) is the liver manifestation and clinical feature of metabolic syndrome.NAFLD described the wild spectrum of liver damage,ranging from simple steatosis to n