Discovery of Individual Difference in Whole-genome Methylation Sequencing Data

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：liuliea

【摘要】

：

Hepatitis B virus (HBV) infection remains a severe global health issue causing hepatitis or hepatocellular carcinoma.Other study confirmed that DNA methyltransferase genes (DNMTS)were unregulated and

【作者】

：

何秋顺纪志梁

【机构】

：

厦门大学生命科学学院,细胞应激生物学国家重点实验室,厦门361102

【出处】

：

第七届全国生物信息学与系统生物学学术大会

【发表日期】

：

2016年8期

【关键词】

：

Hepatitis Methylation Individual Difference

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Hepatitis B virus (HBV) infection remains a severe global health issue causing hepatitis or hepatocellular carcinoma.Other study confirmed that DNA methyltransferase genes (DNMTS)were unregulated and then it decreased viral gene expression,in the meanwhile,changed host CpG islands methylation.To find out differentially methylated position (DMP) and mechanism,12 normal and hepatitis samples for each were analysed after whole-genome methylation sequencing.Principal component analysis (PCA) revealed individual difference of the same class of samples.It suggested that individual difference is a reason cannot be neglected of the different methylated status of genome.

其他文献

Nucleosome Distributions on TSS Flanking Region and Its Relation to Gene Expression in Yeast

On basis of the single-base pair resolution map of nucleosome positions in yeast given by Brogaard et al.and the gene annotation information of yeast,we analyzed the nucleosome distribution patterns a

会议

yeastnucleosome distributiontranscription start sitenucleosome free regionge

The relative importance of various chromatin features for predicting TF-TF co-occupancy

Binding of transcription factor(TF) to specific sequences is a pivotal step in the regulation of gene expression.TF accurately regulate gene expression by binding with other mechanism.The previous stu

会议

transcription factorhistone modificationschromatin features

Correlation between Chromatin Multiple Interaction and Histone Modification

Background: Higher-order chromatin structure of eukaryotes is a key regulator of gene transcription in a long range[1].By high-throughput chromosome conformation capture (Hi-C) technique[2],interactio

会议

Hi-CChromatin Multiple InteractionHistone Modification

Conflicts of DNA methylation and CpG density are involved in alternative promoter usage and genome s

The pattern of DNA methylation is shaped by different factors including CpG dinucleotide density.To globally evaluate the relationship between CpG density and DNA methylation,an algorithm was develope

会议

DNA methylationEpigenomeWGBS

The role of histone acetylation in the regulation of the initiation of DNA replication in Saccharomy

The accurate regulation of the initiation of DNA replication in eukaryotic cells is a key study in gene expression,and the research about replication initiation proteins also draws attention.The histo

会议

Histone acetylationDNA replicationSaccharomyces cerevisiaeReal-time PCR

QCNUP: a quality control pipeline for MNase-seq data

Nucleosomes are the basic units of chromatin,playing an important role in regulating interaction between DNA and proteins,resulting in influence on gene expression.Due to its feature that spread over

会议

Nucleosome positioningQuality ControlDatabase

Influence Factors on the Correlations between Expression Levels of Neighboring Pattern Genes

Genes that exhibit differential expression behaviors are called pattern genes (Pan et al.,2012).Four kinds of pattern genes include housekeeping gene (HKgene),specific gene (Spgene),selective gene (Se

会议

Gene expressionPattern geneAcetylationMethylationGene OntologySemantics

Modeling Enhancer-promoter interactions based on genomic signatures

Enhancer-promoter regulation is important for underlying differential transcriptional regulation.However,there is still a lack of valid prediction methods to link real enhancers and their target promo

会议

enhancer-promoter interactionstranscription factorshistone modificationsDNA m

A deformation energy-based model for predicting nucleosome positions

Nucleosome has been a extensively studied topic not only because its position affects directly cellular processes,such as DNA replication,recombination,and transcription,but also because it severs as

会议

BioinformaticsBending energyRotational positioning

Mutation Breeding of Streptomyces mobaraense to improve TGase production

Transglutaminase (TGase) is an important multifunctional enzyme,which catalyzes acyl transfer reactions between the γ-carboxyamide group of a peptide bound glutamine residue and the ε-amino group of a

会议

TransglutaminaseStreptomyces mobaraenseAtmospheric and Room Temperature Plasma

Discovery of Individual Difference in Whole-genome Methylation Sequencing Data

与本文相关的学术论文