Effect of the cellular cholesterol on the expression of human ACAT1 56-kD isoform

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：uuukns111

【摘要】

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1 State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science

【作者】

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Dong-Qing Guo Guang-Jing Hu Jia-Jia Xu Xiao-Nan Zhao Jia Chen Ming Zhu Lei Qian Catherine C.Y.Chang Bao-Liang Song Ta-Yuan Chang Ying Xiong Bo-Liang Li

【机构】

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KeyLaboratoryofGeriatrics,BeijingInstituteofGeriatrics&BeijingHospital,MinistryofHealthDepartmentofB

【出处】

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2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

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2014年10期

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1 State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesAcyl-coenzyme A∶cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl ester from cholesterol and long-chain fatty acyl-coenzyme A, and is a key enzyme in the cellular cholesterol metabolism.So far, two human ACAT1 isoforms (50-and 56-kD) have been identified.We have previously reported that the expression of 50-kD isoform and chromosome 1-derived ACAT1 mRNA can be up-regulated by the inflammatory factor interferon-g (IFN-g) or tumor necrosis factor-a (TNF-a) specifically in human monocytic cells.

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Effect of the cellular cholesterol on the expression of human ACAT1 56-kD isoform

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