【摘 要】
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Objective To investigate the early changes in serum calcium (Ca) and phosphorus (P) content and bone mineral density of the femoral head,following steroid administration and to clarify the timing of t
【机 构】
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Institute of Biomedicine and Biotechnology,Shenzhen Institute of Advanced Technology,Chinese Academy
【出 处】
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中华医学会第七次骨质疏松和骨矿盐疾病中青年学术会议
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Objective To investigate the early changes in serum calcium (Ca) and phosphorus (P) content and bone mineral density of the femoral head,following steroid administration and to clarify the timing of the abnormal bone mineral development in steroid-induced osteonecrosis (ON).Methods A rabbit model was utilized for this study.Rabbits were injected with 4 mg/kg of methylprednisolone and then divided into three time points (3,7 and 14 days) consisting of 15 rabbits each.Ten control rabbits were kept in the same conditions but did not receive a steroid injection.Histology sections of the bilateral femora were stained with haematoxylin-eosin and used to measure the rate of development of ON.Also,using the special kit,serum Ca and P were measured.Micro-CT was used to measure BMD.
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