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Five new prenylated isoindolinone derivatives,named stachbotrysins A-E (1-5),along with two known congeners (6-7).were isolated from the fungus Stachybotrys chartarum CGMCC 3.5365.Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data.Compounds 1-3 and 7 exhibited significant anti-HIV activity with IC50 values ranging 1.0-9.6 μM,and compound 7 also showed moderate cytotoxicity against HepG2 and NCI-H460 cell lines with IC50 values of 20.1 and 29.3 μM,respectively.