【摘 要】
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Objective This study demonstrated that volume perfusion computer tomography(VPCT)parameters may indicate vascular abnormality in a lung tumor model and reflect the “Vascular Normalization” effect afte
【机 构】
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Department of Radiology,Xiangya hospital,Central South University
【出 处】
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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
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Objective This study demonstrated that volume perfusion computer tomography(VPCT)parameters may indicate vascular abnormality in a lung tumor model and reflect the “Vascular Normalization” effect after Bevacizumab treatment.Methods and Methods One cohort of BALB/c nu/nu mice(N = 30),inoculated with human A549 lung adenocarcinoma cell lines,was treated with Bevacizumab at day0(baseline),and another cohort(N = 30)was treated with equal volume of saline.Longitudinal VPCT studies and pathological examinations [including microvessel pericyte coverage index(MPI)and hypoxia] were performed at day0,day2,day4,day6 and day10.Tumor blood flow(BF)were determined using VPCT method,quantitative measures of vessel maturity by calculating MPI were determined using multiplexed QDs-based immunohistochemical staining and degree of tumor hypoxia were detected by exogenous hypoxia marker using immunohistochemical staining with 60 lesions analyzed retrospectively.
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