【摘 要】
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The right dose of daunorubicin (DNR) for the treatment of newly diagnosed acute myeloid leukemia (AML)is uncertain.Previous trials have shown conflicting re
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The right dose of daunorubicin (DNR) for the treatment of newly diagnosed acute myeloid leukemia (AML)is uncertain.Previous trials have shown conflicting results concerning the efficacy of high or low doses of daunorubicin to induction chemotherapy for newly diagnosed AML.A systematic review and meta-analysis was conducted to resolve this controversial issue.We compared the efficacy and safety of high doses of daunorubicin (HD-DNR) and traditional low doses of daunorubicin (LD-DNR) or idarubicin (IDA) during induction therapy of newly diagnosed AML.Data of 3,824 patients from 1,796 articles in the literature were retrieved and six randomized controlled trials were analyzed.The primary outcomes were overall survival (OS), disease-free survival (DFS), and event-free survival (EFS).The secondary outcomes included complete remission (CR),relapse, and adverse events.
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