【摘 要】
：
A large amount of experimental data on the effects of the nonsteroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-1,2 (COX-1,2) have revealed a significant variability in IC50 and COX-1/COX-2
【机 构】
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Centre for Systems Biology of Edinburgh(CSBE)School of Biological Sciences University of Edinburgh U
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
A large amount of experimental data on the effects of the nonsteroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-1,2 (COX-1,2) have revealed a significant variability in IC50 and COX-1/COX-2 selectivity indexes,registered for the same drug in different experimental settings.The observed values strongly depend on the type of the experiment (in vitro/in vivo) and the cell assay (whole blood assay,platelets,endothelial cells,and others).
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